Kinetic intermediates in amyloid assembly.
نویسندگان
چکیده
In contrast to an expected Ostwald-like ripening of amyloid assemblies, the nucleating core of the Dutch mutant of the Aβ peptide of Alzheimer's disease assembles through a series of conformational transitions. Structural characterization of the intermediate assemblies by isotope-edited IR and solid-state NMR reveals unexpected strand orientation intermediates and suggests new nucleation mechanisms in a progressive assembly pathway.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 136 43 شماره
صفحات -
تاریخ انتشار 2014